Resources


Database Credentialed Access

ICU SLEEP

Ryan Tesh, Hao Deng, Kaileigh Gallagher, Wolfgang Ganglberger, Timothy T. Houle, B. Taylor Thompson, Robert Thomas, Oluwaseun Akeju, M Brandon Westover

De-identified data and analysis code from ICU-SLEEP (NCT03355053): a phase 2 double-blind placebo-controlled three-arm RCT of overnight IV dexmedetomidine in 482 non-ventilated MGH ICU adults aged 50+ (2019-2022).

sedation dexmedetomidine clinical trial delirium icu critical care sleep eeg

Published: April 25, 2026. Version: 1.0.0

Database Open Access

VE-CAM-S: Visual EEG-Based Grading of Delirium Severity and Associations with Clinical Outcomes

Ryan Tesh, Haoqi Sun, Jin Jing, Mike Westmeijer, Anudeepthi Neelagiri, Subapriya Rajan, Parimala Velpula Krishnamurthy, Pooja Sikka, Syed Quadri, Michael Leone, Luis Paixao, Ezhil Panneerselvam, Christine Eckhardt, Aaron F Struck, Peter Kaplan, Oluwaseun Akeju, Daniel Jones, Eyal Kimchi, M Brandon Westover

This dataset supports a published prospective cohort study using machine learning to develop the Visual EEG Confusion Assessment Method Severity (VE-CAM-S) scale for quantifying delirium and coma severity.

Published: Jan. 5, 2024. Version: 1.0

Database Restricted Access

E-CAM-S: Physiological Assessment of Delirium Severity: The Electroencephalographic Confusion Assessment Method Severity Score

Meike van Sleuwen, Haoqi Sun, Christine Eckhardt, Anudeepthi Neelagiri, Ryan Tesh, Mike Westmeijer, Luis Paixao, Subapriya Rajan, Parimala Velpula Krishnamurthy, Pooja Sikka, Michael Leone, Ezhil Panneerselvam, Syed Quadri, Aditya Gupta, Manohar Ghanta, Valdery Moura Junior, Oluwaseun Akeju, Eyal Kimchi, M Brandon Westover

Data and code for quantifying delirium severity using EEG signals, from van Sleuwen et al. 2022, "The Electroencephalographic Confusion Assessment Method Severity Score (E-CAM-S)."

Published: Nov. 13, 2023. Version: 1.0

Database Credentialed Access

Neurophysiologic Encephalopathy Severity Index (NESI) - Data and Code

Arka Roy, Katelyn Surrao, ChenXi Sun, Jin Jing, Tianyu Zhang, Aditya Gupta, Ryan A. Tesh, Imad Akbar, Kaileigh Gallagher, Marjan Sarami, Rajib Kanti Dey, Aysenur Yaramis, Alihan Yaramis, Zeeshan Haider, Utsav Patel, Laraib Jumani, Grace Bayas, Haoqi Sun, Wolfgang Ganglberger, Erika L. Juarez Martinez, Fábio A. Nascimento, Irfan S. Sheikh, Oluwaseun Akeju, Miles Berger, Eyal Y. Kimchi, Sahar F. Zafar, Christine A. Eckhardt, M Brandon Westover

A continuous, EEG-based index of encephalopathy severity (NESI) that maps RASS, GCS, CAM-S, and ICANS onto one physiological axis. Includes 10-minute EEG segments, MORGOTH features, trained models, derived tables, and the full analysis code.

Published: June 14, 2026. Version: 1.0.0