Resources


Database Credentialed Access

ELUCID: Late-Onset Unexplained Epilepsy as a Risk Factor for Cognitive Impairment and Dementia — A Multi-Center Prospective Longitudinal Study (Protocol and Data Resource)

Alice Lam, Emily Johnson, rani sarkis, Leah J. Blank, Tyler E. Gaston, Mouhsin Shafi, Rodrigo Zepeda, Niyatee Samudra, Keith A. Vossel, Ifrah Zawar, Douglas N. Greve, Lori B. Chibnik, Rebecca E. Amariglio, Gad A. Marshall, M. Brandon Westover

ELUCID is a 7-center longitudinal study of 600 adults aged 55+ with late-onset unexplained epilepsy, building a multimodal biorepository (brain MRI, overnight EEG, cognitive testing, blood biomarkers) to identify risk factors for dementia.

Published: July 29, 2026. Version: 1.0.0

Software Credentialed Access

Effects of epileptiform activity on discharge outcome in critically ill patients

Harsh Parikh, Kentaro Hoffman, Haoqi Sun, Sahar F. Zafar, Wendong Ge, Jin Jing, Lin Liu, Jimeng Sun, Aaron F Struck, Alexander Volfovsky, Cynthia Rudin, M. Brandon Westover

De-identified data and a PK-PD + MALTS causal-inference pipeline reproducing the effect of untreated epileptiform-activity burden on poor discharge outcome in critically ill patients (Parikh et al., Lancet Digital Health 2023).

Published: July 11, 2026. Version: 1.0.1

Software Credentialed Access

Automated annotation of epileptiform burden and its association with outcomes

Sahar F. Zafar, Eric Rosenthal, Jin Jing, Wendong Ge, Mohammad Tabaeizadeh, Hassan Aboul Nour, Maryum Shoukat, Haoqi Sun, Farrukh Javed, Solomon Kassa, Muhammad Edhi, Elahe Bordbar, John Gallagher, Valdery Moura, Manohar Ghanta, Yu-Ping Shao, Sungtae An, Jimeng Sun, Andrew J. Cole, M. Brandon Westover

MATLAB code and de-identified data (1,991 patients) relating automatically-quantified ictal-interictal-continuum/seizure burden on continuous EEG to discharge outcome (Zafar et al., Ann Neurol 2021).

Published: July 11, 2026. Version: 1.0.0

Software Credentialed Access

How many patients do you need? A trial-design simulation for anti-seizure treatment in acute brain injury

Harsh Parikh, Haoqi Sun, Rajesh Amerineni, Eric Rosenthal, Alexander Volfovsky, Cynthia Rudin, M. Brandon Westover, Sahar F. Zafar

MATLAB/Python code and de-identified data for a simulation framework that estimates required sample sizes and effect sizes for randomized trials of anti-seizure treatment in critically ill patients (Parikh et al., Ann Clin Transl Neurol 2024).

Published: July 11, 2026. Version: 1.0.0

Software Credentialed Access

Optimal spindle detection parameters for predicting cognitive performance

Noor Adra, Haoqi Sun, Wolfgang Ganglberger, Elissa Ye, Lena L. Dümmer, Ryan A. Tesh, Mike Westmeijer, Madalena D. S. Cardoso, Erin Kitchener, An Ouyang, Joel Salinas, Jonathan Rosand, Sydney Cash, Robert Thomas, M. Brandon Westover

De-identified sleep-spindle feature data (BDSP-linked) + cognition data + Python code to find the spindle-detection parameters that best predict cognitive performance (Adra et al., Sleep 2022).

Published: July 10, 2026. Version: 1.0.0

Software Credentialed Access

Epileptiform activity and outcomes in toxic-metabolic encephalopathy

Paul M. Chen, Saskia S. Schuurmans Stekhoven, Hiba Haider, Jin Jing, Wendong Ge, Eric Rosenthal, M. Brandon Westover, Sahar F. Zafar

De-identified data and reproduction code for a retrospective cEEG study of ictal-interictal continuum patterns and outcomes in 121 patients with toxic-metabolic encephalopathy (MGH, 2012-2017).

Published: July 10, 2026. Version: 1.0.0

Software Credentialed Access

Interpretable quantitative criteria for evaluating interictal epileptiform discharges

Fábio A. Nascimento, Jaden D. Barfuss, A. Jaffe, M. Brandon Westover, Jin Jing

MATLAB code and de-identified data for six interpretable quantitative EEG features (amplitude, duration, sharpness, slow wave, asymmetry, field) combined to classify interictal epileptiform discharges (AUC ~0.83).

Published: July 9, 2026. Version: 1.0.0

Software Credentialed Access

Time-dependent risk of seizures in critically ill patients on continuous electroencephalogram

Aaron F Struck, Gamaleldin Osman, Nishi Rampal, Siddhartha Biswal, Benjamin Legros, Lawrence J. Hirsch, M. Brandon Westover, Nicolas Gaspard

R (mstate) and MATLAB code with de-identified data for a 3-state multistate survival model of time-dependent seizure risk on continuous EEG in critically ill patients (665 consecutive cEEGs).

Published: July 8, 2026. Version: 1.0.0

Software Credentialed Access

Noise in the diagnosis of epilepsy by experts

Fábio A. Nascimento, John McLaren, Wei Zhao, Roohi Katyal, Irfan S. Sheikh, Wan-Yee Kong, Danah Aljaafari, Nirav Barot, Selim Benbadis, Daniel Friedman, Jay R Gavvala, Jonathan Halford, R. Edward Hogan, Peter Kaplan, Ioannis Karakis, Atul Maheshwari, Rebecca Matthews, Cormac O'Donovan, Stefan Rampp, Stephan Schuele, Joseph Sirven, William O. Tatum, Jonathan Williams, Elza Marcia Yacubian, Doyle Yuan, Sándor Beniczky, Olivier Sibony, M. Brandon Westover

Twenty epileptologists diagnosed 50 suspected-seizure vignettes on two occasions; a Bayesian hierarchical model decomposes diagnostic variability into signal and noise. Code + de-identified data.

Published: July 7, 2026. Version: 1.0.0

Software Credentialed Access

NeuroBrowser: Rapid Annotation of Interictal Epileptiform Discharges via Template Matching under Dynamic Time Warping

Jin Jing, M. Brandon Westover

Ultrafast EEG template matching under Dynamic Time Warping for rapid annotation of interictal epileptiform discharges, with an open-source Python implementation and a demo dataset.

Published: July 2, 2026. Version: 1.0.0